Fentanyls

fentanyls
  • Actiq
  • Durogesic
  • Cynril
  • Abstral
  • Fenhuma
  • Effentora
  • Instanyl
  • PecFent

Drugs A-Z

Scientific Names: N-(1-(2-phenethyl)-4-piperidinyl-N-phenyl-propanamide

Generic Names: Fentanyl(s), Synthetic opioids

Examples of types of fentanyls: Acetylfentanyl, alpha-methyfentanyl, Furanylfentanyl, Carfentanil

An example of what Fentanyls looks like
  • Fentanyl is a synthetic opioid which acts as an analgesic. The drug is similar to morphine; however, it is 50 to 100 times more potent. Prescription/medical Fentanyl comes in patches, pills, tablets, lozenges, injectable solution.
  • Many similar drugs (analogues) of fentanyl have been developed both legitimately for use in medicine and other ones illicitly for use as street drugs. These are commonly referred to as fentanyls. The potency of the various fentanyls varies considerably and can be much higher than that of fentanyl.
  • Illegally made fentanyls are sold in power form, impregnated in blotting paper, as tablets and has been found as an adulterant in a number of street drugs. This has led to a huge increase in overdose deaths in the U.S and Canada, although at present fentanyl as either a street drug of choice or as an adulterant in heroin is relatively rare in the UK.

Desired Effects:

  • Intense high
  • Euphoria
  • Relaxation
  • Pain relief

Side Effects:

  • Drowsiness
  • Confusion
  • Sedation
  • Sweating
  • Itching
  • Nausea
If you are knowingly using fentanyl:
  • Don’t use alone.
  • Always have naloxone available. Fentanyl is an opioid. Naloxone reverses the effect of an opioid overdose.
  • Use slow/less. Because fentanyl is so strong, a little goes a long way (compared to heroin!) and overdoses can occur quickly, sometimes before you’ve finished injecting the dose.
  • Try snorting or smoking instead of injecting. Injecting carries the highest risk for overdose, so shifting to snorting or smoking may help reduce risk. You can still OD by smoking/ snorting, especially with fentanyl, so start slow.

As a precaution if you are using heroin:
It is almost impossible to tell whether heroin has been mixed with fentanyls or other potent synthetic opioids just by looking at it. If you think your heroin could contain fentanyls there are some things, you can do to reduce your risk of harm:
  • Use a test strip on your heroin or other street drugs (these are available from drug services).
  • Don’t use alone.
  • Always have naloxone with you. You may need more naloxone to recover from a fentanyl overdose than you would from heroin.
  • Smoke a small amount on foil before attempting to inject. You are less likely to die from smoking adulterated heroin because you would usually fall unconscious before inhaling a lethal amount.
  • If you’re injecting, start with a dose that is a quarter of what you usually use.
  • Don’t ‘slam’ your hit. Depress the plunger slowly, pausing to allow the familiar dose to take effect. If you feel it is unusually strong or sedating, pull it out.
  • Be aware of the signs of overdose and make sure anyone you live with or use with knows them too. In case of emergency, use naloxone and ring for an ambulance.

Long term risks:

Tolerance and dependence.

Short term risks:

  • Injecting related injuries and infections (Hepatitis B, C and HIV, septicaemia).
  • Overdose: Fentanyls are more likely to lead to overdose death than heroin.


Although there are few people choosing to use fentanyls or taking other drugs adulterated with fentanyls, there were still 60 deaths related to fentanyl and 2 related to fentanyl analogues in England and Wales in 2024.
Fentanyls binds to opioid receptors in the brain and body.
Fentanyls can be injected, snorted, swallowed, sucked as a lollypop. It is also taken accidently when it is mis-sold as heroin or found as an adulterant in heroin and some other drugs, although this is relatively rare in the UK.
If snorted:
Razor blade, hard level surface (such as a mirror or glass), tube or rolled banknote.

If smoked:
Tinfoil, matches or lighter, cigarette papers, tobacco.

If injected:
Needle and Syringe, water, Citric acid, matches or lighter, spoon, Tourniquet, Swabs.
Pain relief, analgesic
Some fentanyls are legitimate pharmaceutical products. These occasionally make their way on to the illicit drugs market in the UK. Fentanyl analogues were mostly produced in China where they were legal. However, recent Chinese laws were changed which seems to have led to a reduction in production and a switch to other synthetic opioids. Currently this is most commonly a range of drugs known as ‘Nitazenes’. Nitazenes have recently been found in drugs sold as oxycodone tablets. Some fentanyls are knowingly brought from the internet and used as illicit street drugs
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